Ilse Denise Jacobsen

The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment

This study identifies the Efg1 regulon active in C. albicans during growth in human urine, validates its clinical relevance in catheter samples, and characterizes key downstream factors involved in fungal CAUTI.

The murine lung microbiome is dynamic and transient

This study shows the murine lung microbiome is dynamic and transient, with bacteria rapidly cleared by the immune system and not establishing stable colonization.

Vancomycin impairs macrophage fungal killing by disrupting mitochondrial morphology and function

This study shows vancomycin impairs macrophage fungal killing by disrupting mitochondrial function and morphology, independent of microbiome effects.

Synergistic cross-kingdom host cell damage between Candida albicans and Enterococcus faecalis

This study shows that Candida albicans and Enterococcus faecalis synergistically increase host cell damage through physical interaction and glucose depletion.

Identification of a fungal antibacterial endopeptidase that modulates immune responses

The paper identifies a fungal endopeptidase, CwhA, that cleaves Gram-positive bacterial peptidoglycan, leading to bacterial lysis and immune stimulation.

Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice

This study shows that human CEACAM receptors in mice worsen inflammation and organ damage during Candida albicans infection, leading to shorter survival.

The murine lung microbiome is dysbalanced by the human pathogenic fungus Aspergillus fumigatus resulting in enrichment of anaerobic bacteria

This study shows that Aspergillus fumigatus infection in immunosuppressed mice disrupts lung microbiome balance, increasing anaerobic bacteria like Ligilactobacillus murinus, which can be internalized by epithelial cells.

Multiplex genetic engineering exploiting pyrimidine salvage pathway-based self-encoded selectable markers

This paper introduces a novel genetic engineering method using endogenous pyrimidine salvage pathway genes as selectable markers for targeted DNA insertion in fungal pathogens.