ASD-ASSOCIATED CNTNAP2 VARIANTS DISRUPT NEURONAL ARBORIZATION THROUGH IMPAIRED REGULATION BY ECTODOMAIN SHEDDING
Miguel Lobete, Leonardo E. Dionisio, Emmarose McCoig, Nicolas H. Piguel, Benjamin P. Spielman, Silvia Socas, Marc Dos Santos, Cristina Boers-Escuder, Peter Penzes, María Dolores Martin‐de‐Saavedra
This study shows that ASD-associated CNTNAP2 variants reduce sCNTNAP2 levels and impair dendritic arborization through disrupted ectodomain shedding.
bioRxiv · Nov 4, 2024 · PreprintNeuroscience