María Dolores Martin‐de‐Saavedra

This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.

This study shows that ASD-associated CNTNAP2 variants reduce sCNTNAP2 levels and impair dendritic arborization through disrupted ectodomain shedding.

This study shows that palmitoylation of AnkG-190 stabilizes its localization in dendritic spines, and lithium reduces this modification, affecting its function and interaction with PSD-95.

This study identifies PRRT2 as a key hub in an epilepsy network disrupted by 16p11.2 duplication and shows its correction rescues multiple neuropsychiatric and seizure-related phenotypes in mice.

This study identifies Par3 as a binding partner of CNTNAP2, showing that Par3 localizes CNTNAP2 to endosomes and stabilizes its presence there.

The paper uses advanced microscopy techniques to study dynamic properties of dendritic spinules in live neurons, identifying distinct classes with different lifespans and regulatory mechanisms.