Benjamin P. Spielman

This study shows that in utero exposure to anti-Caspr2 antibodies reduces PV+ interneurons and disrupts inhibitory circuitry in the hippocampus, linking it to ASD-related behavioral impairments.

The paper examines four new anti-Caspr2 antibodies, showing they target different epitopes and induce varying ASD-like phenotypes in male mice offspring.

This study shows that ASD-associated CNTNAP2 variants reduce sCNTNAP2 levels and impair dendritic arborization through disrupted ectodomain shedding.