Real-time analysis of pore formation by bi-component staphylococcal leukotoxins using the two-electrode voltage-clamp technique
Laura Lemel, Simon HARRIS, Guillaume Audic, Laure Bellard, Jean‐Daniel Savoie, Claire M. Grison, Sébastien Granier, Justine Magnat, Normand Voyer, Thierry Vernet, Isabel D. Alves, Anne Marie Di Guilmi, Christophe Moreau
This paper develops an electrophysiological method to study pore formation by bi-component staphylococcal leukotoxins in real-time using Xenopus oocytes, revealing receptor-dependent kinetics and a hybrid model of subunit oligomerization.
bioRxiv · Aug 4, 2026 · PreprintMicrobiology