Phage-Assisted Evolution of Allosteric Protein Switches
Nicholas T. Southern, Adrian Bachmann, Alisa Hovsepyan, Marielouise Griebl, Benedict Wolf, Nina Lemmen, Ann-Sophie Helene Kroell, Simon Westermann, Jan Mathony, Dominik Niopek
This paper develops a phage-assisted evolution platform to engineer allosteric protein switches, achieving near-binary optogenetic switches with high dynamic range.
Nature Communications · Apr 14, 2026Peer-reviewedSynthetic Biology