Drosophila SA1 expression prevents brain tumorigenesis and PARP-mediated cell elimination
Simona Totaro, Antonella Lettieri, Silvia Castiglioni, Francesco Lavezzari, Cristina Gervasini, Valentina Massa, Thomas Vaccari
The paper investigates the role of cohesin complex variants in brain tumorigenesis and shows that reduced cohesin activity increases apoptosis, which can be exploited through PARP inhibition.
bioRxiv · Apr 18, 2025 · PreprintCancer Biology