Occupationally Relevant Wildfire Smoke Inhalation Impairs Nitric Oxide Signaling and Promotes Progressive Aortic Stiffening in Hypercholesterolemic Mice
Jacqueline Matz, Victoria A. Williams, Matthew Eden, Hannah I.B. Wilker, Simone Sabnis, Ye Chen, Paola Sebastiani B, Michael J. Gollner, Jessica M. Oakes, Chiara Maria Bellini
This study shows that wildfire smoke exposure in hypercholesterolemic mice causes vascular inflammation, oxidative stress, and fibrosis, leading to aortic stiffening and hypertension.
bioRxiv · May 20, 2026 · PreprintPharmacology & Toxicology