Ye Chen

Structural Lung Remodeling Precedes Functional Decline After Chronic Smoldering Douglas Fir Smoke Exposure in Apoe-/- Mice

This study shows that structural and molecular lung damage occurs before functional decline in mice exposed to smoke, highlighting the need for early biomarkers in firefighters.

Occupationally Relevant Wildfire Smoke Inhalation Impairs Nitric Oxide Signaling and Promotes Progressive Aortic Stiffening in Hypercholesterolemic Mice

This study shows that wildfire smoke exposure in hypercholesterolemic mice causes vascular inflammation, oxidative stress, and fibrosis, leading to aortic stiffening and hypertension.

UniCure: A Foundation Model for Predicting Personalized Cancer Therapy Response

UniCure predicts personalized cancer therapy response by integrating omics and chemical models, achieving high accuracy in drug response and combination effects across diverse data.

Integrative analysis across metagenomic taxonomic classifiers: A case study of the gut microbiome in aging and longevity

This study compares two metagenomic classifiers, finds classifier-specific results, and recommends integrating multiple classifiers to better capture age-associated taxa.