Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons
Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Marialaina Nissenbaum, Alexander W. Kusnecov, Qian Cai
This study shows that boosting mitochondrial bioenergetics enhances autophagy and clears pathological tau in tauopathy neurons, suggesting a new therapeutic approach for Alzheimer's and other tauopathies.
bioRxiv · Feb 12, 2024 · PreprintNeuroscience