Marialaina Nissenbaum

Dysregulation of a novel autophagosome-mitochondria contact contributes to autophagy dysfunction and neurodegeneration in tauopathy

This study identifies dysregulated autophagosome-mitochondria contacts in tauopathy, showing that restoring these contacts improves autophagy and reduces tau pathology.

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

This study shows that neuronal DAMPs activate astrocytic RIPK3 signaling, leading to neuroinflammation and dopaminergic cell death in Parkinson's disease.

Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons

This study shows that boosting mitochondrial bioenergetics enhances autophagy and clears pathological tau in tauopathy neurons, suggesting a new therapeutic approach for Alzheimer's and other tauopathies.