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Siobhan M. Hughes

Scripps Research Institute

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Approach:experimental assay· 1

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Gabriel C. LanderiD· 1 shared Ian J. MacRaeiD· 1 shared Saikat ChowdhuryiD· 1 shared Todd A. AnzeloniD· 1 shared Yao XiaoiD· 1 shared

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Molecular BiologyNaturePeer-reviewedSep 1, 2021

Structural basis for piRNA-targeting

Todd A. Anzelon, Saikat Chowdhury, Siobhan M. Hughes…·Ian J. MacRae

This paper presents cryo-EM structures of Piwi-piRNA complexes and analyzes their target recognition mechanism, revealing how Piwi ensures targeting fidelity and adapts to genomic threats.

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experimental assay

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