Human hindbrain organoids with segment-specific 5-HT neurons for motor modulation
Jinkui Zhu, Wei Pang, Yantong Liu, Yao Yin, Xiaoxiang Lu, Jianfeng Wei, Linlin Jiang, Wei Zhou, Yajing Cao, Qinzhi Zhang, Sisi Chen, Siyuan Chu, Zhaoxuan Ji, Die Hong, Yuanyuan Li, , 向阳飞
This study generates human hindbrain organoids with segment-specific 5-HT neurons to model serotonergic development and motor modulation, revealing DISC1 deficiency disrupts serotonergic development and motor function.
bioRxiv · May 29, 2026 · PreprintNeuroscience