Muscle March5 restrains an ATF4-GDF15 endocrine stress axis that modulates feeding and body composition
Guixing Ma, Yuehua Chen, Siyuan Cheng, Yangshan Chen, Wei Pang, Litong Chen, Huiling Cao
This study identifies March5 as a muscle proteostatic checkpoint that limits ATF4-dependent GDF15 production, linking muscle health to feeding and body composition.
bioRxiv · Jul 10, 2026 · PreprintPhysiology