Yangfei Xiang

This study generates human hindbrain organoids with segment-specific 5-HT neurons to model serotonergic development and motor modulation, revealing DISC1 deficiency disrupts serotonergic development and motor function.

This study uses longitudinal single-nucleus RNA sequencing to analyze transcriptional dynamics in SCA1 cerebellum, identifying early cellular changes and applying deep learning to predict disease state.

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

This study investigates how the dyslexia-associated gene KIAA0319 regulates cell cycle during human neuroepithelium development, linking it to reading disability through effects on neuronal progenitor cells.