Stable but not rigid: Long-term in vivo STED nanoscopy uncovers extensive remodeling of stable spines and indicates multiple drivers of structural plasticity
Heinz Steffens, Alexander Charles Mott, Siyuan Li, Waja Wegner, Pavel Švehla, Vanessa W. Y. Kan, Fred Wolf, Sabine Liebscher, Katrin I. Willig
This study uses in vivo STED nanoscopy to show that dendritic spines undergo extensive remodeling over time, with both volatile and stable components, and this is exaggerated in a neurodegeneration model.
Science Advances · Jun 9, 2021Peer-reviewedNeuroscience