Human pluripotent stem cell-derived intestinal epithelial cells maintain small intestine-specific functions over time, even with repeated cell division
Junlong Chen, So Kuramochi, Shinichiro Horiuchi, Tomoyuki Kawasaki, Hidehiro Κakizaki, Lirika Tabata, Tohru Kimura, Kazuaki Nakamura, Hidenori Akutsu, Seiichi Ishida, Atsuo Kikuchi, Akihiro Umezawa
This study compares drug metabolic capacity and cytotoxicity of Caco-2 cells, cryopreserved enterocytes, and stem cell-derived intestinal epithelial cells to identify a better model for drug discovery.
bioRxiv · Feb 17, 2025 · PreprintCell Biology