Akihiro Umezawa

This paper develops human iPSC-derived bone marrow organoids that support both hematopoiesis and thymus-like T cell differentiation, offering a platform for immune cell therapy and research.

This study compares drug metabolic capacity and cytotoxicity of Caco-2 cells, cryopreserved enterocytes, and stem cell-derived intestinal epithelial cells to identify a better model for drug discovery.

This study develops an automated xeno-free system for efficient chondrogenic differentiation of human embryonic stem cells, producing high-quality cartilage suitable for clinical applications.

This study uses whole-genome sequencing of 9,850 Japanese samples to analyze genetic diversity, revealing population declines and natural selection linked to agriculture and food production.

The paper identifies SHOX as a sex-biased gene with random monoallelic expression contributing to sex differences in height.

This study shows that inhibiting N-myristoyltransferase (Nmt) promotes naive pluripotency in both mouse and human pluripotent stem cells.