Collateral damage: Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina A. Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna C. Pass, Thomas Keane, David J. Adams, Abigail Saffron Tucker, Jacqueline K. White, Karen P. Steel
The paper identifies and characterizes spontaneous mutations causing deafness in mice from a targeted knockout program, showing these mutations are a common side effect of intensive breeding.
BMC Biology · Mar 16, 2022Peer-reviewedGenetics