XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans
Amitesh Panda, Leo Carrillo, Bradley Philip Balaton, Jeanne Brouillet, Solomon Nshemereirwe, Jarne Bonroy, Charbel Alfeghaly, Romina Facchinello, Sherif Khodeer, Ruben Boers, Gaël Castel, Charlie London, Emmanuel Cazottes, Madeleine Moscatelli, Raissa Songwa Tchinda, , Vincent Pasque
This study shows that XIST is required for XCI in human extraembryonic cells, which is essential for their survival and development.
bioRxiv · Nov 19, 2025 · PreprintDevelopmental Biology