Emmanuel Cazottes

Evaluation of Active Learning Selection Strategies and Characterization of Informative Sequences for Sequence-to-Expression Models

This study evaluates active learning strategies for sequence-to-expression models, finding that uncertainty-based methods outperform random sampling and identify informative sequences with distinct biological features.

XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans

This study shows that XIST is required for XCI in human extraembryonic cells, which is essential for their survival and development.

XIST dampens X chromosome activity in a SPEN-dependent manner during early human development

The paper shows XIST reduces X chromosome activity through SPEN-dependent mechanisms before XCI in human embryos, while XACT does not significantly affect XIST function.

Extensive remodelling of XIST regulatory networks during primate evolution

The paper examines how XIST regulatory networks evolve in primates, showing extensive diversification and the role of transposons and enhancers in different species.