Claire Rougeulle

This study shows that XIST is required for XCI in human extraembryonic cells, which is essential for their survival and development.

The paper identifies a novel XACT lncRNA transcript expressed in both active and inactive X chromosomes, with roles in erythroid differentiation and AML subtypes beyond its role in XCI.

The paper shows XIST reduces X chromosome activity through SPEN-dependent mechanisms before XCI in human embryos, while XACT does not significantly affect XIST function.

The paper examines how XIST regulatory networks evolve in primates, showing extensive diversification and the role of transposons and enhancers in different species.

The paper identifies a primate-specific retroviral enhancer that integrates the XACT lncRNA into the human pluripotency network through evolutionary adaptation.

The paper investigates the mechanistic differences in XIST regulatory networks between humans and mice, showing that JPX regulates XIST expression through distinct mechanisms in each species.