Pharmacology & ToxicologyACS Chemical BiologyPeer-reviewed
Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Anti-Tumor Immunity In Vivo and in Patient-Derived Cells
Somaya A. Abdel-Rahman, Zamara Mariam, Giuseppe Deganutti, Moustafa Tarek Gabr
This study identifies GL-4512, a small molecule modulator of LILRB4, which restores anti-tumor immunity in vivo and in patient-derived cells by disrupting immunosuppressive signaling.
DOI 10.1021/acschembio.6c00486