Zamara Mariam

PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners

This study compares the functional and structural properties of the intracellular agonist PCO371 with the extracellular peptide agonist PTH 1-34 at the PTH1R, revealing PCO371's non-biased signaling profile and lower potency.

Direct Small Molecule Modulation of LILRB4 (ILT3) Restores Anti-Tumor Immunity In Vivo and in Patient-Derived Cells

This study identifies GL-4512, a small molecule modulator of LILRB4, which restores anti-tumor immunity in vivo and in patient-derived cells by disrupting immunosuppressive signaling.

In vivo functional profiling and structural characterisation of the human Glp1r A316T variant

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking

This study identifies GLP-1 analogues with prolonged signaling by modifying specific amino acids, showing how receptor trafficking and peptide structure affect signaling duration.