Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics
Juho Alaviuhkola, Sondos Abdulmajeed, Sven T. Sowa, Johan Pääkkönen, L. Lehtiö
The paper identifies 15 inhibitors of bacterial Arr enzymes that ADP-ribosylate rifamycin antibiotics, with structural insights into their selectivity.
ACS Chemical Biology · Jun 13, 2025Peer-reviewedBiochemistry