Author
University of OuluORCID 0000-0001-7411-5925Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Chiara Bosetti, Albert Galera‐Prat, Sven T. Sowa…·L. Lehtiö
The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.
Juho Alaviuhkola, Sondos Abdulmajeed, Sven T. Sowa…·L. Lehtiö
The paper identifies 15 inhibitors of bacterial Arr enzymes that ADP-ribosylate rifamycin antibiotics, with structural insights into their selectivity.
Sven T. Sowa, Chiara Bosetti, Albert Galera‐Prat…·L. Lehtiö
This study investigates the evolutionary origin and conservation of tankyrases across species, showing their presence in choanoflagellates and conservation of core functions despite varying interaction partners.
Lilian C. Russo, Rebeka Tomasin, Isaac de Araújo Matos…·Nícolas C. Hoch
This paper shows that the SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling in human cells.