Johan Pääkkönen

Dimerization of human PARP15 is required for NAD+ binding and automodification

This study shows that dimerization of PARP15 is necessary for NAD+ binding and automodification, supported by structural and biochemical evidence.

Discovery of Tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain

The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.

Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics

The paper identifies 15 inhibitors of bacterial Arr enzymes that ADP-ribosylate rifamycin antibiotics, with structural insights into their selectivity.

Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

This study identifies pyrrolo-pyrimidine-based Mac1 inhibitors that inhibit MHV and SARS-CoV-2 replication, with some compounds showing IFN-dependent antiviral activity.