VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation
Sung‐Hyun Hwang, Mingyun Bae, Ji‐Won Kim, Seung Yoon Hyun, Kui‐Jin Kim, Joshua H. Choe, Min Jung Kim, Ji Won Park, Seung‐Yong Jeong, Songji Choi, Woochan Park, Jeongmin Seo, Heejung Chae, Min-Su Kang, Eun Hee Jung, , Keun‐Wook Lee
This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology