This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.

bioRxiv · Sep 16, 2025 · PreprintCancer Biology

Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer

David Lukacsovich, Wini V. Zambare, Chao Wu, Hanchen Huang, Wei Zhang, Min Jung Kim, Janet A. Alvarez, Aron Bercz, Philip B. Paty, Paul Bernard Romesser, Lily Wang, J. Joshua Smith, Xi Chen

This study integrates DNA methylation profiles from tumors and organoids to identify CpGs predictive of chemotherapy response in rectal cancer, finding a methylation risk score significantly predicts progression-free survival.

medRxiv · Feb 28, 2025 · PreprintGenetic & Genomic Medicine

Extensive mosaicism by somatic L1 retrotransposition in normal human cells

Chang Hyun Nam, Jeonghwan Youk, Jeong Yeon Kim, Joonoh Lim, Jung Woo Park, Soo Ah Oh, Hyun Jung Lee, Hyein Won, Dong-Sung Lee, Seung‐Yong Jeong, Ji Won Oh, Jinju Han, Junehawk Lee, Hyun Woo Kwon, Min Jung Kim, Young Seok Ju

The paper analyzes somatic L1 retrotranspositions in single-cell genomes from normal human tissues, finding high prevalence in colorectal cells and revealing epigenetic mechanisms driving retrotransposition.

Nature · May 10, 2023Peer-reviewedGenomics