Author

Sophia Gross

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

CAROL J. DEUTSCHiD· 2 shared Aaron SykesiD· 1 shared Aaron Sykes· 1 shared Lannawill CaruthiD· 1 shared LiWei Tu· 1 shared Shefali S. VermaiD· 1 shared Therese Davis· 1 shared Toshinori HoshiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersPhysiology

CAROL J. DEUTSCHORCID

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2 papers

Recent·Most cited

Early-stage determinants of T1-S1 conformations in Kv1.3 channels

LiWei Tu, Aaron Sykes, Therese Davis, Sophia Gross, CAROL J. DEUTSCH

This study identifies molecular determinants of early-stage folding in Kv1.3 channels, revealing dynamic interfaces and domain interactions that influence tetramerization and conformation.

Journal of Molecular Biology · Oct 5, 2025Peer-reviewedPhysiology

Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding.

Aaron Sykes, Lannawill Caruth, Sophia Gross, Shefali S. Verma, Toshinori Hoshi, CAROL J. DEUTSCH

This study investigates how disease-associated Kv1.3 variants affect protein folding and stability, finding that R114G variant shows reduced folding probability and structural instability.

Journal of Molecular Biology · May 21, 2025Peer-reviewedPhysiology