Author

CAROL J. DEUTSCH

University of PennsylvaniaORCID 0000-0003-1475-5562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Sophia Gross· 2 shared Aaron SykesiD· 1 shared Aaron Sykes· 1 shared Lannawill CaruthiD· 1 shared LiWei Tu· 1 shared Shefali S. VermaiD· 1 shared Therese Davis· 1 shared Toshinori HoshiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

Sophia Gross

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PhysiologyJournal of Molecular BiologyPeer-reviewedOct 5, 2025

Early-stage determinants of T1-S1 conformations in Kv1.3 channels

LiWei Tu, Aaron Sykes, Therese Davis…·CAROL J. DEUTSCH

This study identifies molecular determinants of early-stage folding in Kv1.3 channels, revealing dynamic interfaces and domain interactions that influence tetramerization and conformation.

DOI 10.1016/j.jmb.2025.169474

proteomicsexperimental assay

𝕏 PostBluesky

PhysiologyJournal of Molecular BiologyPeer-reviewedMay 21, 2025

Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding.

Aaron Sykes, Lannawill Caruth, Sophia Gross…·CAROL J. DEUTSCH

This study investigates how disease-associated Kv1.3 variants affect protein folding and stability, finding that R114G variant shows reduced folding probability and structural instability.

DOI 10.1016/j.jmb.2025.169226

humanproteomics

𝕏 PostBluesky