Timed Secreted Proteomes Reveal Regulation of Hepatokines by the Liver Circadian Clock
Christopher Litwin, Qing Zhang, Ioannis Tsialtas, Zhihong Li, Sophia Hernandez, Steffi Prem, Kristi Dietert, Mallory Keating, Tomoki Sato, Jiyoon Ryu, Lily Dong, Kevin F. Bieniek, Kevin B. Koronowski
The paper identifies time-of-day-dependent liver protein secretion in mice, revealing endostatin's role in regulating adipose metabolism through circadian control.
Nature Communications · Jun 2, 2026Peer-reviewedMolecular Biology