Pura Muñoz‐Cánoves

Visualizing the Epigenetic Landscape of Aging and Cellular Reprogramming: Optimized ATAC-see for Cells and Tissues

The paper optimizes ATAC-see for high-throughput chromatin accessibility imaging in aging and reprogramming, revealing age-related chromatin changes and reprogramming-induced remodeling.

Targeted ATAC-see (tATAC-see): A Visual Assay for Target-Specific Chromatin Profiling

tATAC-see captures target-specific chromatin states using a visual assay, showing dynamic remodeling in aging models and LAD resistance.

The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function

This study shows the liver clock regulates transcriptional rhythms in skeletal muscle, affecting mitochondrial function through endocrine communication.

The central clock drives metabolic rhythms in muscle stem cells

This study shows that the central clock controls metabolic rhythms in muscle stem cells, independent of the local stem cell clock, and highlights the role of autophagy and lipid metabolism in this process.

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.

Network-community analysis of cellular senescence

The paper applies network-based methods to identify genetic markers of cellular senescence using cell-type-resolved RNA sequencing data from injured mouse muscle tissue.

Impact of Bmal1 rescue and time-restricted feeding on liver and muscle proteomes during the active phase in mice

The paper investigates how Bmal1 rescue and time-restricted feeding affect liver and muscle proteomes in mice, finding BMAL1 has a greater impact than feeding cycles.