Kevin F. Bieniek

This study quantifies astrocyte reactivity and morphological changes in a ferret TBI model using AI and atlas-based mapping, revealing region-specific responses and structural remodeling.

This study investigates the effects of PLCγ2 deficiency in mice, showing impaired immune tolerance, myelin homeostasis disruption, and enhanced oxidative metabolism in the brain.

The paper identifies time-of-day-dependent liver protein secretion in mice, revealing endostatin's role in regulating adipose metabolism through circadian control.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This study identifies microglia-dependent and independent mechanisms of lipid dysregulation in Alzheimer's disease using mouse models and lipidomics.

The paper validates a non-PFAS, proton-free solvent for ex vivo MRI scanning as a potential replacement for fluorinated solvents.

This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.

This study investigates the effects of PLCγ2 deficiency in mouse brains using multi-omics approaches, revealing sex-specific changes in lipid and gene expression that may link to Alzheimer's disease and aging.