Author

Sophie Low

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Michelle C. CipicchioiD· 2 shared Niall J. LennoniD· 2 shared Adam Slamin· 1 shared Akanksha KhorgadeiD· 1 shared Allison Brookhart· 1 shared Anasha Arryman· 1 shared Andrew Bernier· 1 shared April Jung· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Michelle C. CipicchioORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Scalable single-cell isoform profiling with sequencing-by-expansion

Christophe H. Georgescu, Ghamdan Al‐Eryani, Allison Brookhart, Jagdeesh Chandrasekar, Stephanie J. Yaung, Megan Rogers-Peckham, Megan Freer, Michael E. Kartje, Houlin Yu, Akanksha Khorgade, Charlotte Yang, Lacey McGee, Kendall Berg, Cynthia Cech, Salka Barrett, , Aziz M. Al’Khafaji

This paper introduces a high-throughput single-cell RNA isoform sequencing method using sequencing-by-expansion (SBX) and the CUDLL algorithm, achieving high accuracy and enabling isoform-level analysis across cell types.

bioRxiv · Jul 28, 2026 · PreprintGenetics

Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform

Gilad Almogy, Mark Pratt, Florian C. Oberstrass, Linda Lee, Dan Mazur, Nate Beckett, Omer Barad, Ilya Soifer, Eddie Perelman, Yoav Etzioni, Martin Sosa, April Jung, Tyson A. Clark, Eliane H. Trepagnier, Gila Lithwick‐Yanai, , Doron Lipson

Open flow cell on a circular wafer with mostly natural nucleotides and no reversible terminators: about 300 bp reads at $1/Gb, 99.6% SNP accuracy on reference human genomes.

bioRxiv · May 29, 2022 · PreprintGenomics