Author

Florian C. Oberstrass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Doron LipsoniD· 4 shared Gila Lithwick‐YanaiiD· 3 shared Nika IremadzeiD· 3 shared Gilad Almogy· 2 shared Omer BaradiD· 2 shared Tyson A. ClarkiD· 2 shared Aaron M. HorningiD· 1 shared Alexander LeNailiD· 1 shared

Activity by Year

2022-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersGenomics

Doron LipsonORCID

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4 papers

Recent·Most cited

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Joseph M. Replogle, Reuben A. Saunders, Angela N. Pogson, Jeffrey A. Hussmann, Alexander LeNail, Alina Guna, Lauren G. Mascibroda, Eric J. Wagner, Karen Adelman, Gila Lithwick‐Yanai, Nika Iremadze, Florian C. Oberstrass, Doron Lipson, Jessica L. Bonnar, Marco Jost, , Jonathan S. Weissman

The paper performs genome-scale Perturb-seq to map genotype-phenotype relationships, uncovering new gene functions and stress-specific mitochondrial regulation.

Cell · Jun 9, 2022Peer-reviewedGenomics

Ultra high-throughput whole-genome methylation sequencing reveals trajectories in precancerous polyps to early colorectal adenocarcinoma

Hayan Lee, Gat Krieger, Tyson A. Clark, Aziz Khan, Casey Ryan Hanson, Yizhou Zhu, Nasim Bararpour, Aaron M. Horning, Edward D. Esplin, Stephanie A. Nevins, Annika K K Weimer, Eti Meiri, Shlomit Gilad, Sima Benjamin, Danit Lebanony, , Michael P. Snyder

The paper uses ultra high-throughput methylation sequencing to study DNA methylation changes during colorectal cancer progression from normal tissue to adenocarcinoma.

bioRxiv · May 30, 2022 · PreprintGenomics

Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform

Gilad Almogy, Mark Pratt, Florian C. Oberstrass, Linda Lee, Dan Mazur, Nate Beckett, Omer Barad, Ilya Soifer, Eddie Perelman, Yoav Etzioni, Martin Sosa, April Jung, Tyson A. Clark, Eliane H. Trepagnier, Gila Lithwick‐Yanai, , Doron Lipson

Open flow cell on a circular wafer with mostly natural nucleotides and no reversible terminators: about 300 bp reads at $1/Gb, 99.6% SNP accuracy on reference human genomes.

bioRxiv · May 29, 2022 · PreprintGenomics

Single cell RNA-seq by mostly-natural sequencing by synthesis

Sean Simmons, Gila Lithwick‐Yanai, Xian Adiconis, Florian C. Oberstrass, Nika Iremadze, Kathryn Geiger-Schuller, Pratiksha I. Thakore, Chris J. Frangieh, Omer Barad, Gilad Almogy, Orit Rozenblatt–Rosen, Aviv Regev, Doron Lipson, Joshua Z. Levin

The paper benchmarks a new low-cost sequencing by synthesis method for scRNA-seq, showing comparable results to existing technologies and enabling cost-effective large-scale applications.

bioRxiv · May 29, 2022 · PreprintGenomics