Linda Lee

A microRNA CRISPR screen reveals miR-483-3p as an apoptotic regulator in prostate cancer

The paper uses a CRISPR-based screen to identify miR-483-3p as a key apoptotic regulator in prostate cancer, showing its role in cell survival and potential as a therapeutic target.

Cost-efficient whole genome-sequencing using novel mostly natural sequencing-by-synthesis chemistry and open fluidics platform

Open flow cell on a circular wafer with mostly natural nucleotides and no reversible terminators: about 300 bp reads at $1/Gb, 99.6% SNP accuracy on reference human genomes.

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

This study shows DNA-PK promotes MRN and phosphorylated CtIP for efficient DNA end processing, facilitating the transition from non-homologous end joining to homologous recombination.