NeuroscienceAlzheimer s & DementiaPeer-reviewed
Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice
Melvin W. King, Sophie M. Jacob, Ashish Sharma…·Erik S. Musiek
This study shows that disrupting the central circadian clock in 5xFAD mice under a light-dark cycle reduces amyloid plaque and tau phosphorylation, suggesting a complex interaction between circadian rhythms and Alzheimer's pathology.
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