Author

Melvin W. King

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Erik S. MusiekiD· 2 shared Jennifer H. LawrenceiD· 2 shared Asha D. Patel· 1 shared Ashish SharmaiD· 1 shared Collin J. NadarajahiD· 1 shared Richard DanemaniD· 1 shared Sophie M. Jacob· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Erik S. MusiekORCID

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2 papers

Recent·Most cited

Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice

Melvin W. King, Sophie M. Jacob, Ashish Sharma, Jennifer H. Lawrence, Erik S. Musiek

This study shows that disrupting the central circadian clock in 5xFAD mice under a light-dark cycle reduces amyloid plaque and tau phosphorylation, suggesting a complex interaction between circadian rhythms and Alzheimer's pathology.

Alzheimer s & Dementia · Nov 1, 2025Peer-reviewedNeuroscience

Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown

Jennifer H. Lawrence, Asha D. Patel, Melvin W. King, Collin J. Nadarajah, Richard Daneman, Erik S. Musiek

This study shows that microglia drive diurnal variation in BBB permeability during inflammation, with increased BBB breakdown following evening LPS injection.

JCI Insight · Nov 7, 2024Peer-reviewedNeuroscience