Jennifer H. Lawrence

Complement component C4 regulates amyloid pathology and glial reactivity in mouse model of Alzheimer's Disease

This study shows that C4 deficiency reduces amyloid plaques and neuroinflammation in a mouse AD model, suggesting C4's role in glial reactivity and pathology.

Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice

This study shows that disrupting the central circadian clock in 5xFAD mice under a light-dark cycle reduces amyloid plaque and tau phosphorylation, suggesting a complex interaction between circadian rhythms and Alzheimer's pathology.

A glial circadian gene expression atlas reveals cell type and disease-specific reprogramming in response to amyloid pathology or aging.

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown

This study shows that microglia drive diurnal variation in BBB permeability during inflammation, with increased BBB breakdown following evening LPS injection.