Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein
Sumangal Roychowdhury, Souradip Paul, Kandarp A. Sojitra, Sounak Bhattacharya, Abhishek Mazumder, Jeetain Mittal, Krishnananda Chattopadhyay
This study investigates how heterotypic protein interactions affect α-synuclein condensate dynamics and aggregation, showing that multivalent electrostatic interactions drive co-condensation and promote amyloid fibril formation.
bioRxiv · Jul 10, 2025 · PreprintBiophysics