Sumangal Roychowdhury

Crowder induced conformational fluctuations modulate the phase separation of yeast SUP35 NM domain

This study shows that crowder shape affects Sup35NM conformation and phase separation, with rod-like crowders promoting phase separation while spherical ones do not.

Heterotypic FG-Nup98-tau condensates form nested assemblies through stoichiometry-dependent phase transitions

This study investigates how FG-Nup98 and tau form heterotypic condensates through phase transitions, revealing their potential role in disrupting nuclear pore permeability.

Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells

This study identifies PIEZO1 mechanosensing as a key regulator of ligand-specific TLR9 signaling in human pDCs, showing that CpGA induces IFN production via membrane tension and PIEZO1 activation, while CpGB does not.

Heterotypic Protein Interactions Modulate the Condensate Dynamics and Aggregation of α-Synuclein

This study investigates how heterotypic protein interactions affect α-synuclein condensate dynamics and aggregation, showing that multivalent electrostatic interactions drive co-condensation and promote amyloid fibril formation.

Amyloid Beta Oligomers Accelerate ATP-Dependent Phase Separation of Ago2 to RNA Processing Bodies

This study shows amyloid beta oligomers enhance Ago2 phase separation to RNA processing bodies by promoting miRNA-mRNA targeting, while HuR counteracts this effect.