BiochemistrybioRxivPreprint
ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1
Suman Panda, Tanaya Roychowdhury, Anindya Dutta…·Subhrangsu Chatterjee
This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.
DOI 10.1101/2024.02.01.578345