Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction
Min Jae Lee, Jason R. Hunt, Soyoung Cho, Travis J. Chiarelli, Christofer N. Perry, Jason A. Carlyon, Mark Hochstrasser
This study identifies small-molecule inhibitors of the bacterial deubiquitylating enzyme OtDUB, showing they reduce O. tsutsugamushi infection in cells.
bioRxiv · Jun 26, 2026 · PreprintBiochemistry