Min Jae Lee

Ubiquitin Receptor-Induced Proximity is Sufficient for Ubiquitin-Independent Targeted Protein Degradation via the 26S Proteasome

This paper introduces Protea-Tac, a Ub-independent protein degrader that targets proteins to the proteasome, demonstrating in vivo tumor suppression.

Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction

This study identifies small-molecule inhibitors of the bacterial deubiquitylating enzyme OtDUB, showing they reduce O. tsutsugamushi infection in cells.

Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy

This paper demonstrates that AUTOTAC, a targeted degradation approach, reduces tau aggregates and improves symptoms in tauopathy models and companion dogs.

USP15: the fourth Proteasome-associated DUB

The paper identifies USP15 as a fourth proteasome-associated DUB, showing it binds transiently to proteasomes and selectively disassembles short polyubiquitin chains.

Cholesterol binding to VCAM-1 promotes vascular inflammation

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.