Mark Hochstrasser

Small-molecule inhibition of the Orientia tsutsugamushi deubiquitylating enzyme OtDUB impairs bacterial reproduction

This study identifies small-molecule inhibitors of the bacterial deubiquitylating enzyme OtDUB, showing they reduce O. tsutsugamushi infection in cells.

AMPK alters proteasome phosphorylation status and prevents persistent proteasome condensates

This study shows AMPK regulates proteasome phosphorylation and prevents persistent proteasome condensates in yeast by modulating kinase-phosphatase activity.

Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast

The paper identifies protein-protein interactions and proteolytic activity as key factors determining the functional replaceability of human proteasome subunits in yeast.