Divergent TDP43-regulated and TDP43-independent cryptic splicing in the cortex and spinal cord
Dwight F. Newton, Rena Yang, Johnny Gutierrez, Jeffrey W. Hofmann, Sreedevi Chalasani, Felix L. Yeh, Anne Biever, Brad A. Friedman
The paper identifies 142 cryptic splices in ALS and FTD tissues, revealing divergent splicing between spinal cord and cortex, and highlights TDP43-independent events.
Molecular Neurodegeneration Advances · Jan 6, 2026Peer-reviewedNeuroscience