Anne Biever

The paper identifies 142 cryptic splices in ALS and FTD tissues, revealing divergent splicing between spinal cord and cortex, and highlights TDP43-independent events.

This study identifies the classical complement pathway as a therapeutic target in Alzheimer's disease and demonstrates the efficacy of antisense oligonucleotides in rescuing synapse loss in mouse models.

The paper identifies and quantifies the transcriptome and translatome in neuronal cell bodies, dendrites, and axons using RNA-seq and Ribo-seq, revealing that local translation is a major source of synaptic proteins.

The paper shows that monosomes, not polysomes, are the main sites of active translation for synaptic mRNAs in neuronal processes, contributing to local protein synthesis.