Author

Brad A. Friedman

GenentechORCID 0000-0002-5864-5253Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:database / resource· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Oded ForemaniD· 3 shared Caspar GlockiD· 2 shared Jeffrey W. HofmanniD· 2 shared Jesse E. HansoniD· 2 shared Ainhoa Etxeberría· 1 shared Alyaa M. Abdel‐HaleemiD· 1 shared Anne BieveriD· 1 shared Benjamin I. LauferiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Oded ForemanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Soma-seq links intracellular protein states to transcriptional programs in the human brain

Carmen Sandoval-Filarsky, Caspar Glock, José Miguel Andrade López, Max Adrian, Vishwa Talati, Oded Foreman, Jeffrey W. Hofmann, Casper C. Hoogenraad, Orit Rozenblatt–Rosen, Brad A. Friedman, Michelle B. Chen

Soma-seq measures both RNA and intracellular proteins in single human brain cells, revealing protein states linked to transcriptional programs in Alzheimer's disease.

bioRxiv · May 29, 2026 · PreprintNeuroscience

Divergent TDP43-regulated and TDP43-independent cryptic splicing in the cortex and spinal cord

Dwight F. Newton, Rena Yang, Johnny Gutierrez, Jeffrey W. Hofmann, Sreedevi Chalasani, Felix L. Yeh, Anne Biever, Brad A. Friedman

The paper identifies 142 cryptic splices in ALS and FTD tissues, revealing divergent splicing between spinal cord and cortex, and highlights TDP43-independent events.

Molecular Neurodegeneration Advances · Jan 6, 2026Peer-reviewedNeuroscience

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration

Tawaun A. Lucas, Gloriia Novikova, Sadhna Rao, Yuanyuan Wang, Benjamin I. Laufer, Shristi Pandey, Michelle G. Webb, Nikolas L. Jorstad, Brad A. Friedman, Jesse E. Hanson, Joshua S. Kaminker

The paper constructs an integrated atlas of astrocytes from human and mouse neurodegenerative disease models, identifying conserved and divergent subtypes across species.

bioRxiv · Feb 12, 2025 · PreprintNeuroscience

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Yuanyuan Wang, Tiffany Z. Wu, Ming‐Chi Tsai, Mitchell G. Rezzonico, Alyaa M. Abdel‐Haleem, Luke Xie, Vineela D. Gandham, Hai Ngu, Kimberly L. Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A. Friedman, Morgan Sheng, Jesse E. Hanson

This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.

eLife · Jul 31, 2023Peer-reviewedNeuroscience

Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation

Karpagam Srinivasan, Brad A. Friedman, Ainhoa Etxeberría, Melanie A. Huntley, Marcel P. van der Brug, Oded Foreman, Jonathan S. Paw, Zora D. Modrusan, Thomas G. Beach, Geidy E. Serrano, David V. Hansen

The paper identifies a novel transcriptional signature in human Alzheimer's myeloid cells that differs from mouse models and shows aging-related and AD-specific gene expression changes.

Cell Reports · Jun 1, 2020Peer-reviewedNeuroscience