Author

Stéphanie Fiola

Centre de recherche du CHU de Québec-Université Laval

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

André Machado XavieriD· 3 shared David GosseliniD· 3 shared Félix Distéfano‐GagnéiD· 3 shared Serge RivestiD· 3 shared Nesrine BelhamitiiD· 2 shared Sara BitarafaniD· 2 shared Sarah Belhocine· 2 shared Alexia Falle· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

André Machado XavierORCID

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3 papers

Recent·Most cited

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelination

Félix Distéfano‐Gagné, Nesrine Belhamiti, William Saxon, Sara Bitarafan, André Machado Xavier, Stéphanie Fiola, Serge Rivest, David Gosselin

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

bioRxiv · Aug 21, 2025 · PreprintNeuroscience

Systematic delineation of signaling and epigenomic mechanisms underlying microglia inflammatory activity in acute and chronic brain pathologies

André Machado Xavier, Félix Distéfano‐Gagné, Nesrine Belhamiti, Sarah Belhocine, Sara Bitarafan, Alexia Falle, Stéphanie Fiola, Serge Rivest, David Gosselin

This study identifies signaling and epigenomic mechanisms regulating microglia inflammatory activity through multi-omics analyses of gene expression, chromatin accessibility, and transcription factor activity in acute and chronic brain pathologies.

bioRxiv · Aug 4, 2022 · PreprintNeuroscience

Context-dependent transcriptional regulation of microglial proliferation

Sarah Belhocine, André Machado Xavier, Félix Distéfano‐Gagné, Stéphanie Fiola, Serge Rivest, David Gosselin

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.

Glia · Dec 4, 2021Peer-reviewedGenomics